233 BISPHOSPHONATES: ANOTHER COMPLEX DRUG TO PRESCRIBE
نویسندگان
چکیده
Abstract Background Bisphosphonates provide effective treatment for osteoporosis. They accumulate a bone reservoir lasting 3 years and beyond. The 2021 NICE guidelines recommend medication review ‘drug holiday’ after 5 of oral bisphosphonate therapy low-fracture risk patients. Continuing high individuals is advised: age=/>75, previous hip or vertebral fracture, one more fractures during treatment, recent DEXA scan with T score =/<−2.5, and/or current glucocorticoids. This retrospective audit aimed to assess compliance in primary care setting. Methods Data were collected using the Health One online medical record system an urban general practice. Inclusion criteria: all patients =/> 65 old, prescribed osteoporosis >5 years. Exclusion deceased, did not attend clinic >1 year, on conditions other than Results 137 history identified. 76 greater Of patients, 33 classified as appropriately commenced drug holiday, while 22 correctly remained bisphosphonates due fracture risk. remaining 21 inappropriately continued without receiving review, repeat fracture-risk assessment. Conclusion third beyond assessed holiday. aim reduce poly-pharmacy prevent rare but serious long-term adverse events (such atypical fractures, osteonecrosis jaw, gastric cancer atrial fibrillation). Factors which had impact inappropriate prescribing should be assessed. Incorporating computer-based alerts could support safe practices.
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Department of Screening for Gastrointestinal Cancer 1 , Department of Cancer Epidemiology2, Department of Gastroenterology3, Department of Epidemiology and Mass Examination of Cardiovascular Diseases4, Osaka Medical Center for Cancer and Cardiovascular Diseases. 3-3 Nakamichi 1-Chome, Higashinari-Ku, Osaka 537-8511, Japan; Department of Hygiene and Preventive Medicine, Osaka University School o...
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ژورنال
عنوان ژورنال: Age and Ageing
سال: 2021
ISSN: ['1468-2834', '0002-0729']
DOI: https://doi.org/10.1093/ageing/afab219.233